The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair.

@article{Liang2016TheAI,
  title={The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair.},
  author={Diana Hwang Liang and Dong Soon Choi and Joe Ensor and Benny Abraham Kaipparettu and Barbara Bass and Jenny C. Chang},
  journal={Cancer letters},
  year={2016},
  volume={376 2},
  pages={249-58}
}
Triple negative breast cancer (TNBC), characterized by an abundance of treatment-resistant breast cancer stem cells (CSCs), has a poorer prognosis than other types of breast cancers. Despite its aggressiveness, no effective targeted therapy exists for TNBC. Here, we demonstrate that CQ effectively targets CSCs via autophagy inhibition, mitochondrial structural damage, and impairment of double-stranded DNA break repair. Electron microscopy demonstrates CQ-induced mitochondrial cristae damage… CONTINUE READING
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