The autophagosome: origins unknown, biogenesis complex

  title={The autophagosome: origins unknown, biogenesis complex},
  author={Christopher A. Lamb and Tamotsu Yoshimori and Sharon A Tooze},
  journal={Nature Reviews Molecular Cell Biology},
Healthy cells use autophagy as a general 'housekeeping' mechanism and to survive stress, including stress induced by nutrient deprivation. Autophagy is initiated at the isolation membrane (originally termed the phagophore), and the coordinated action of ATG (autophagy-related) proteins results in the expansion of this membrane to form the autophagosome. Although the biogenesis of the isolation membrane and the autophagosome is complex and incompletely understood, insight has been gained into… CONTINUE READING
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