The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell.

@article{Romano2007TheAP,
  title={The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell.},
  author={Patricia Silvia Romano and Maximiliano G Gutierrez and Walter Ber{\'o}n and Michel Rabinovitch and Mar{\'i}a Isabel Colombo},
  journal={Cellular microbiology},
  year={2007},
  volume={9 4},
  pages={
          891-909
        }
}
The etiologic agent of Q fever Coxiella burnetii, is an intracellular obligate parasite that develops large vacuoles with phagolysosomal characteristics, containing multiple replicating bacteria. We have previously shown that Phase II C. burnetii replicative vacuoles generated after 24-48 h post infection are decorated with the autophagic protein LC3. The aim of the present study was to examine, at earlier stages of infection, the distribution and roles of the small GTPases Rab5 and Rab7… CONTINUE READING
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