The autologous mixed lymphocyte reaction in systemic lupus erythematosus.

@article{Riccardi1982TheAM,
  title={The autologous mixed lymphocyte reaction in systemic lupus erythematosus.},
  author={Patrizia Riccardi and Paul Hausman and Howard V. Raff and John D. Stobo},
  journal={Arthritis and rheumatism},
  year={1982},
  volume={25 7},
  pages={
          820-3
        }
}
The autologous mixed lymphocyte reaction (AMLR) represents the proliferation of T cells in response to signals from autologous non-T cells. Fractionation of the non-T population into B enriched and macrophage enriched cells demonstrated that both could serve as effective stimulator cells in the AMLR. Cytolytic treatment of both populations with a macrophage specific, monoclonal antibody abrogated stimulation of the macrophage but not the B cell population. Utilizing a series of negative… CONTINUE READING