The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.

@article{Wang2013TheAG,
  title={The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.},
  author={Yaya Wang and Iftach Shaked and Stephanie M. Stanford and Wenbo Zhou and Julie M. Curtsinger and Zbigniew Mikulski and Zachary R. Shaheen and Genhong Cheng and Kristy Sawatzke and Amanda M Campbell and Jennifer L. Auger and Hatice Kayim Bilgic and Fernanda Miyagaki Shoyama and David O. Schmeling and Henry H. Balfour and Kiminori Hasegawa and Andrew Che-On Chan and John A Corbett and Bryce A Binstadt and Matthew F. Mescher and Klaus Ley and Nunzio Bottini and Erik J. Peterson},
  journal={Immunity},
  year={2013},
  volume={39 1},
  pages={111-22}
}
Immune cells sense microbial products through Toll-like receptors (TLR), which trigger host defense responses including type 1 interferons (IFNs) secretion. A coding polymorphism in the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is a susceptibility allele for human autoimmune and infectious disease. We report that Ptpn22 selectively regulated type 1 IFN production after TLR engagement in myeloid cells. Ptpn22 promoted host antiviral responses and was critical for TLR agonist… CONTINUE READING