The autoimmune reactivity to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis is potentially pathogenic: Effect of copolymer 1 on MOG-induced disease

@article{BenNun1996TheAR,
  title={The autoimmune reactivity to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis is potentially pathogenic: Effect of copolymer 1 on MOG-induced disease},
  author={Avraham Ben-Nun and Itzhack Mendel and Ronit Bakimer and Masha Fridkis-Hareli and Dvora Teitelbaum and Ruth Arnon and Michael Sela and Nicole Kerlero de Rosbo},
  journal={Journal of Neurology},
  year={1996},
  volume={243},
  pages={S14-S22}
}
Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) characterized by primary demyelination, is believed to result from an autoimmune attack against myelin components. In view of their ability to induce experimental autoimmune encephalomyelitis (EAE), an animal model for MS, the quantitatively major myelin proteins — myelin basic protein (MBP) and proteolipid protein (PLP) — have been extensively studied as the relevant primary antigens in MS, and therapeutic… CONTINUE READING