The autocrine/paracrine regulation of thyrotropin secretion.

  title={The autocrine/paracrine regulation of thyrotropin secretion.},
  author={Carmen Cabanelas Pazos-Moura and T M Ortiga-Carvalho and Egberto Gaspar de Moura},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={13 2},
Peptides originally described in other tissues have been located in the anterior pituitary gland. Detection of their encoding mRNAs and specific receptors, together with demonstration of peptide local action led to the postulation of the existence of a paracrine/autocrine regulation of pituitary function. Direct evidence for the role of endogenous peptides has come from studies aiming to block their action through immunoneutralization or pharmacologic blockade. Here we review evidence of… CONTINUE READING