The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.

@article{Yi2017TheAU,
  title={The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.},
  author={Jason J. Yi and Smita R Paranjape and Matthew P Walker and Rajarshi Rai Choudhury and Justin M Wolter and Giulia Fragola and Michael J Emanuele and Michael B. Major and Mark J. Zylka},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 30},
  pages={
          12503-12515
        }
}
UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism, Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked UBE3A mutant (UBE3AT485A) that disrupts phosphorylation control of UBE3A activity. Through quantitative proteomics and reporter assays, we found that the UBE3AT485A protein ubiquitinates multiple… CONTINUE READING