Corpus ID: 23581399

The augmentation of human natural killer cell activity by interferon-gamma is not associated with the induction of the interferon-alpha-inducible proteins.

@article{Gustafsson1986TheAO,
  title={The augmentation of human natural killer cell activity by interferon-gamma is not associated with the induction of the interferon-alpha-inducible proteins.},
  author={A. Gustafsson and S. Sundstr{\"o}m and E. Lundgren},
  journal={Journal of immunology},
  year={1986},
  volume={137 1},
  pages={
          167-71
        }
}
  • A. Gustafsson, S. Sundström, E. Lundgren
  • Published 1986
  • Biology, Medicine
  • Journal of immunology
  • Treatment of partly purified large granular lymphocytes (LGL) with either IFN-alpha or IFN-gamma for 2 hr augmented their NK cell activity. This augmentation was completely inhibited by the addition of 10 micrograms/ml of cycloheximide. In contrast, when the effects of IFN-gamma on the synthesis of specific proteins in these cells was directly studied by use of two-dimensional gel electrophoresis, we found that IFN-gamma was unable to induce any of the earlier detected, IFN-alpha/IFN-beta… CONTINUE READING
    13 Citations
    Interferon--a major regulator of natural killer cell-mediated cytotoxicity.
    • Z. Reiter
    • Biology, Medicine
    • Journal of interferon research
    • 1993
    • 105