The atypical cell cycle regulator Spy1 suppresses differentiation of the neuroblastoma stem cell population

@inproceedings{Lubanska2014TheAC,
  title={The atypical cell cycle regulator Spy1 suppresses differentiation of the neuroblastoma stem cell population},
  author={Dorota D. Lubanska and Lisa Ann Porter},
  booktitle={Oncoscience},
  year={2014}
}
Neuroblastoma is an aggressive pediatric cancer originating embryonically from the neural crest. The heterogeneity of the disease, as most solid tumors, complicates diagnosis and treatment. In neuroblastoma this heterogeneity is well represented in both primary tumours and derived cell lines and has been shown to be driven by a population of stem-like tumour initiating cells. Resolving the molecular mediators driving the division of this population of cells may indicate effective therapeutic… CONTINUE READING

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