The atypical antipsychotics risperidone, clozapine and olanzapine differ regarding their sedative potency in rats.

@article{Ahnaou2003TheAA,
  title={The atypical antipsychotics risperidone, clozapine and olanzapine differ regarding their sedative potency in rats.},
  author={Abdellah Ahnaou and Anton A. P. H. Megens and Wilhelmus H.I.M. Drinkenburg},
  journal={Neuropsychobiology},
  year={2003},
  volume={48 1},
  pages={47-54}
}
The atypical antipsychotics risperidone, clozapine and olanzapine were studied for their ability to antagonise apomorphine-induced stereotypy and to affect electroencephalographic (EEG) activity in rats. The compounds antagonised apomorphine-induced stereotypy with ED(50)s of 0.15 mg/kg s.c. for risperidone, 0.42 mg/kg s.c. for olanzapine and 1.3 mg/kg s.c. for clozapine. At a dose close to that required for apomorphine antagonism (0.16 mg/kg s.c.), risperidone induced only minor changes in EEG… CONTINUE READING