The atypical antipsychotic sertindole enhances efflux of dopamine and its metabolites in the rat cortex and striatum.

Abstract

Previous studies have shown that sertindole (1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl ]-2 imidazolidinone), an atypical antipsychotic drug that is a potent 5-HT2A and dopamine D2 receptor antagonist, preferentially affects mesocorticolimbic rather than mesostriatal dopamine neurons. Using in vivo microdialysis in conscious… (More)

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Cite this paper

@article{Watanabe1999TheAA, title={The atypical antipsychotic sertindole enhances efflux of dopamine and its metabolites in the rat cortex and striatum.}, author={Minoru Watanabe and Yoko Hagino}, journal={European journal of pharmacology}, year={1999}, volume={367 1}, pages={19-23} }