The atypical antidepressant mirtazapine attenuates expression of morphine-induced place preference and motor sensitization.


Opioid abuse and dependence remains prevalent despite having multiple FDA-approved medications to help maintain abstinence. Mirtazapine is an atypical antidepressant receiving attention for substance abuse pharmacotherapy, and its action includes alterations in monoaminergic transmission. As monoamines are indirectly altered by opioids, the current… (More)
DOI: 10.1016/j.brainres.2012.07.007