The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase.

@article{Rosenbaugh2010TheAO,
  title={The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase.},
  author={Erin G Rosenbaugh and James W Roat and Lie Gao and Rui-fang Yang and Devika Soundara Manickam and Jing-Xiang Yin and Harold D Schultz and Tatiana K. Bronich and Elena V. Batrakova and Alexander V Kabanov and Irving H. Zucker and Matthew C Zimmerman},
  journal={Biomaterials},
  year={2010},
  volume={31 19},
  pages={5218-26}
}
Adenoviral-mediated overexpression of the intracellular superoxide (O(2)(*-)) scavenging enzyme copper/zinc superoxide dismutase (CuZnSOD) in the brain attenuates central angiotensin II (AngII)-induced cardiovascular responses. However, the therapeutic potential for adenoviral vectors is weakened by toxicity and the inability of adenoviral vectors to target the brain following peripheral administration. Therefore, we developed a non-viral delivery system in which CuZnSOD protein is… CONTINUE READING
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