The attenuated NYCBH vaccinia virus deleted for the immune evasion gene, E3L, completely protects mice against heterologous challenge with ectromelia virus.

@article{Denzler2011TheAN,
  title={The attenuated NYCBH vaccinia virus deleted for the immune evasion gene, E3L, completely protects mice against heterologous challenge with ectromelia virus.},
  author={Karen L. Denzler and Jill Schriewer and Scott Parker and C .W. de A. Werner and Hollyce Hartzler and Ed Hembrador and Trung Huynh and Susan A. Holechek and R. Mark L. Buller and Bertram L Jacobs},
  journal={Vaccine},
  year={2011},
  volume={29 52},
  pages={9691-6}
}
The New York City Board of Health (NYCBH) vaccinia virus (VACV) vaccine strain was deleted for the immune evasion gene, E3L, and tested for its pathogenicity and ability to protect mice from heterologous challenge with ectromelia virus (ECTV). NYCBHΔE3L was found to be highly attenuated for pathogenicity in a newborn mouse model and showed a similar attenuated phenotype as the NYVAC strain of vaccinia virus. Scarification with one or two doses of the attenuated NYCBHΔE3L was able to protect… CONTINUE READING

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