The atom economy--a search for synthetic efficiency.

@article{Trost1991TheAE,
  title={The atom economy--a search for synthetic efficiency.},
  author={Barry M Trost},
  journal={Science},
  year={1991},
  volume={254 5037},
  pages={1471-7}
}
Efficient synthetic methods required to assemble complex molecular arrays include reactions that are both selective (chemo-, regio-, diastereo-, and enantio-) and economical in atom count (maximum number of atoms of reactants appearing in the products). Methods that involve simply combining two or more building blocks with any other reactant needed only catalytically constitute the highest degree of atom economy. Transition metal-catalyzed methods that are both selective and economical for… CONTINUE READING
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