The athymic nude rat. IV. Immunocytochemical study to detect T-cells, and immunological and histopathological reactions against Trichinella spiralis.

@article{Vos1983TheAN,
  title={The athymic nude rat. IV. Immunocytochemical study to detect T-cells, and immunological and histopathological reactions against Trichinella spiralis.},
  author={Joseph G. Vos and Elis Joost Ruitenberg and N Van Basten and J. Buys and Anneke Elgersma and Wim H. Kruizinga},
  journal={Parasite immunology},
  year={1983},
  volume={5 2},
  pages={
          195-215
        }
}
The anti-parasite response was investigated after oral infection of athymic nude (rnu/rnu) rats and heterozygous (+/rnu) littermates with 1000 muscle larvae of Trichinella spiralis. No IgM, IgG and IgE antibodies were detected in serum of rnu/rnu rats. Expulsion of adult worms from the small intestine was prolonged (worms were nearly all expelled at days 14 and 91 in +/rnu and rnu/rnu rats respectively). The yield of muscle larvae in the carcasses of nude rats at day 91 was 33 times higher than… CONTINUE READING

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