The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses?

@article{Rolstad2001TheAN,
  title={The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses?},
  author={Bent Rolstad},
  journal={Immunological reviews},
  year={2001},
  volume={184},
  pages={
          136-44
        }
}
Athymic nude rats resemble nude mice in their lack of a normal thymus and functionally mature T cells. They have been useful in the study of mechanisms of tumor growth or graft rejection in immunocompromised hosts since they can accept major histocompatibility complex (MHC) mismatched organ allografts or xenografts for several months and because a number of tumor cell lines of human and rodent origin grow well in these rats. Injection of a few helper T (Th) cells from euthymic littermate rats… CONTINUE READING

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