The athlete biological passport.

@article{Sottas2011TheAB,
  title={The athlete biological passport.},
  author={Pierre-Edouard Sottas and Neil Robinson and Olivier Rabin and Martial Saugy},
  journal={Clinical chemistry},
  year={2011},
  volume={57 7},
  pages={
          969-76
        }
}
BACKGROUND In elite sports, the growing availability of doping substances identical to those naturally produced by the human body seriously limits the ability of drug-testing regimes to ensure fairness and protection of health. CONTENT The Athlete Biological Passport (ABP), the new paradigm in testing based on the personalized monitoring of biomarkers of doping, offers the enormous advantage of being independent of this endless pharmaceutical race. Doping triggers physiological changes that… 

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References

SHOWING 1-10 OF 34 REFERENCES

Endogenous steroid profiling in the athlete biological passport.

The athlete's biological passport and indirect markers of blood doping.

Forensic techniques for the evaluation of the evidence, and more particularly Bayesian networks, allow antidoping authorities to take into account firstly the natural variations of indirect markers - through a mathematical formalism based on probabilities - and secondly the complexity due to the multiplicity of causes and confounding effects through a distributed and flexible graphical representation.

Hematologic passport for athletes competing in endurance sports: a feasibility study.

The hematologic passport is feasible and might be employed to exclude athletes with non-physiologic increases in hemoglobin and hematocrit from competitions and should be used within a global strategy to deter blood doping.

Performance profiling: a role for sport science in the fight against doping?

A new strategy to improve the targeting of suspicious athletes might be the longitudinal monitoring of individual performances, which might improve the effectiveness in the fight against doping considerably.

A strategy to deter blood doping in sport.

This article will apply logic to known doping strategies, with an emphasis on the abuse of recombinant human erythropoietin that reflects the prevalence of its abuse in the sporting community.

Statistical Classification of Abnormal Blood Profiles in Athletes

A new indirect and universal test of blood doping, called Abnormal Blood Profile Score (ABPS), is developed, based on the statistical classification of indirect biomarkers of altered erythropoiesis, which is sensitive to any form of blood transfusion, autologous transfusion included.

Second-generation blood tests to detect erythropoietin abuse by athletes.

The increased stability of the new blood parameters facilitates transport of samples to central laboratories, and the heightened sensitivity of thenew models makes them better than existing models for federations wishing to screen samples for urine testing and to identify and target suspect athletes for out-of-competition testing.

Development of reference ranges in elite athletes for markers of altered erythropoiesis.

Assessment of an athlete's blood parameters and ON- and OFF-model scores may need adjustment for training modalities and other characteristics of the subject.

Mass spectrometry in sports drug testing: Structure characterization and analytical assays.

The versatility of modern mass spectrometers enable specific as well as comprehensive measurements allowing sports drug testing laboratories to determine the misuse of therapeutics such as anabolic-androgenic steroids, stimulants, masking agents or so-called designer drugs in athletes' blood or urine specimens, and a selection of recent developments is summarized in this review.