The ataxia telangiectasia-mutated and Rad3-related protein is dispensable for retroviral integration.

@article{Dehart2005TheAT,
  title={The ataxia telangiectasia-mutated and Rad3-related protein is dispensable for retroviral integration.},
  author={Jason L Dehart and Joshua L. Andersen and Erik S. Zimmerman and Orly Ardon and Dong Sung An and Jana L. Blackett and Baek ki Kim and Vicente Planelles},
  journal={Journal of virology},
  year={2005},
  volume={79 3},
  pages={1389-96}
}
Integration into the host cell DNA is an essential part of the retroviral life cycle and is required for the productive replication of a retrovirus. Retroviral integration involves cleavage of the host DNA and insertion of the viral DNA, forming an integration intermediate that contains two gaps, each with a viral 5' flap. The flaps are then removed, and the gap is filled by as yet unidentified nuclease and polymerase activities. It is thought that repair of these gaps flanking the site of… CONTINUE READING

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