The associations between CYP24A1 polymorphisms and cancer susceptibility: A meta-analysis and trial sequential analysis.

  title={The associations between CYP24A1 polymorphisms and cancer susceptibility: A meta-analysis and trial sequential analysis.},
  author={Man Zhu and Shili Qiu and Xianwei Zhang and Yingchao Wang and Tapara Dramani Maman Souraka and Xue Wen and Chunzi Liang and Jiancheng Tu},
  journal={Pathology, research and practice},
  volume={214 1},

Association of the vitamin D metabolism gene GC and CYP27B1 polymorphisms with cancer susceptibility: a meta-analysis and trial sequential analysis

The authors' analyses suggested that rs4588 and rs7041 polymorphisms were significantly associated with overall cancer risk, and appeared to increase the risk of breast cancer and digestive system tumor, but not in prostate cancer and non-small cell lung cancer.

Genetic associations between CYP24A1 polymorphisms and predisposition of cancer: A meta-analysis

A pooled meta-analysis of published studies suggests that the rs4809960 polymorphism may affect the predisposition of cancer in Caucasians, and the rs6022999 polymorphism might affect the susceptibility to cancer in Asians.

Association study between CYP24A1 gene polymorphisms and cancer risk.

A candidate intronic CYP24A1 gene variant affects the risk of colorectal cancer.

Findings indicate that the CYP24A1 rs4809960 polymorphism decreased the risk of CRC in the studied population of patients with CRC and noncancer controls.

Contribution of CYP24A1 variants in coronary heart disease among the Chinese population

It was revealed that CYP24A1 variants were significantly linked with CHD susceptibility in the Chinese population and a four-locus model had significant impact on CHD risk in MDR analysis.

Future Directions of Pharmacovigilance Studies Using Electronic Medical Recording and Human Genetic Databases

It is suggested that electronic medical recording and human genetic databases are considered together in future directions of pharmacovigilance to repurpose clinical and translational research infrastructure and ultimately future personalized therapy considering ADRs.

Gsslasso Cox: a Bayesian hierarchical model for predicting survival and detecting associated genes by incorporating pathway information

A Bayesian hierarchical Cox survival model, called the group spike-and-slab lasso Cox (gsslasso Cox), for predicting disease survival outcomes and detecting associated genes by incorporating group structures of biological pathways by employing a novel prior on the coefficients of genes.



Vitamin D Related Genes, CYP24A1 and CYP27B1, and Colon Cancer Risk

This is the first study to evaluate these genes in relation to colon cancer, and a possible interaction between CYP27B1 and UV-weighted sun exposure with proximal colon cancer was observed.

Comprehensive Association Analysis of the Vitamin D Pathway Genes, VDR, CYP27B1, and CYP24A1, in Prostate Cancer

It is suggested that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer.

No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case–control study

It is found that none of the polymorphisms tested was associated with melanoma risk as well as prognosis in logistic and linear regression models in the study population.

Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans

The results strongly suggest that genetic variation in vitamin D-related genes could affect CRC susceptibility in AAs.

Vitamin D-related gene polymorphisms, plasma 25-hydroxyvitamin D, and breast cancer risk

Breast cancer risk may be associated with specific vitamin D-related polymorphisms, particularly CYP24A1, and genetic variation in the vitamin D pathway should be considered when designing potential intervention strategies with vitamin D supplementation.

Vitamin D Pathway Gene Variants and Prostate Cancer Risk

It is found that there is no strong evidence of altered risk of developing prostate cancer overall or within clinical measures of tumor aggressiveness for any of the tagSNPs when they were assessed individually or in haplotypes.

Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study

A nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort, observed no statistically significant associations between polymorphisms or haplotypes in key vitamin D-related genes and risk of breast cancer.

Genetic Variants in Vitamin D Pathway Genes and Risk of Pancreas Cancer; Results from a Population-Based Case-Control Study in Ontario, Canada

Vitamin D pathway gene variants may be associated with pancreas cancer risk and future studies are needed to understand the possible role of vitamin D in tumorigenesis and may have implications for cancer-prevention strategies.

Genetic Variation in the Vitamin D Pathway in Relation to Risk of Prostate Cancer—Results from the Breast and Prostate Cancer Cohort Consortium

The genetic findings do not support a protective association between loci known to influence vitamin D levels and prostate cancer risk, and genetic variants related to lower 25(OH)D levels were associated with a decreased risk of aggressive prostate cancer.

Vitamin D-Related Gene Polymorphisms, Plasma 25-Hydroxy-Vitamin D, Cigarette Smoke and Non-Small Cell Lung Cancer (NSCLC) Risk

The results suggested that the lower the distribution of vitamin D concentration, the more the genetic variations in CYP24A1, VDR and GC genes may be associated with NSCLC risk.