The association of viral proteins with host cell dynein components during virus infection.

@article{MerinoGracia2011TheAO,
  title={The association of viral proteins with host cell dynein components during virus infection.},
  author={Javier Merino-Gracia and M{\^a}ria Flor Garc{\'i}a-Mayoral and Ignacio Rodr{\'i}guez-Crespo},
  journal={The FEBS journal},
  year={2011},
  volume={278 17},
  pages={2997-3011}
}
After fusion with the cellular plasma membrane or endosomal membranes, viral particles are generally too large to diffuse freely within the crowded cytoplasm environment. Thus, they will never reach the cell nucleus or the perinuclear areas where replication or reverse transcription usually takes place. It has been proposed that many unrelated viruses are transported along microtubules in a retrograde manner using the cellular dynein machinery or, at least, some dynein components. A putative… CONTINUE READING
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