The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese.

@article{Ito2008TheAO,
  title={The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese.},
  author={Michiko Ito and Masayuki Hanaoka and Yunden Droma and Orie Hatayama and Etsuro Sato and Yoshihiko Katsuyama and Keisaku Fujimoto and Masao Ota},
  journal={Internal medicine},
  year={2008},
  volume={47 15},
  pages={1387-94}
}
OBJECTIVE The transforming growth factor beta-1 gene (TGFB1) is one of the most promising candidate genes for chronic obstructive pulmonary disease (COPD). Several case-control studies have been performed and generated inconsistent results. The possible reasons for these discrepancies include the diversity of ethnic populations and the heterogeneity of COPD, including emphysema and airway disease. We designed this study to investigate the association of single nucleotide polymorphisms (SNPs) of… CONTINUE READING

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