The association of tissue transglutaminase with human recombinant tau results in the formation of insoluble filamentous structures.

@article{Appelt1997TheAO,
  title={The association of tissue transglutaminase with human recombinant tau results in the formation of insoluble filamentous structures.},
  author={Denah M. Appelt and Brian J. Balin},
  journal={Brain research},
  year={1997},
  volume={745 1-2},
  pages={21-31}
}
To determine possible mechanisms by which NFTs are formed in Alzheimer's disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombinant tau proteins into insoluble filamentous structures. TGase derived from guinea pig liver was activated by calcium to catalyze the in vitro cross-linking of the largest soluble recombinant tau isoform (htau40) into insoluble complexes as determined by electrophoresis following incubation in 4 M urea and SDS. The TGase… CONTINUE READING
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