The association of the metabolic syndrome with QTc interval in NHANES III


Purpose To examine the relationship of metabolic syndrome with corrected QT interval duration. Methods In a cross-sectional analysis of NHANES III, a representative sample of the adult US population, 3,495 individuals aged ≥40 years were categorized as having metabolic syndrome and not having metabolic syndrome as defined by ATP III. QT interval was measured from the standard 12-lead electrocardiogram. Results A weighted multi-linear regression analysis adjusted for age, gender, serum calcium, and potassium showed that metabolic syndrome was significantly associated with a corrected QT interval in milliseconds. The adjusted Beta coefficient and its corresponding standard error were (4.48 milliseconds, 0.95 milliseconds, P < 0.01). Conclusion These data indicate that metabolic syndrome is independently associated with a corrected QT interval duration. This study calls for careful ECG monitoring among persons with metabolic syndrome for early detection of a long corrected QT interval in order to prevent severe and often fatal arrhythmias.

DOI: 10.1007/s10654-008-9252-4

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@article{Faramawi2008TheAO, title={The association of the metabolic syndrome with QTc interval in NHANES III}, author={Mohammed F. Faramawi and Rachel P. Wildman and Jeanette Gustat and Janet C. Rice and Mohammed Y. Abdul Kareem}, journal={European Journal of Epidemiology}, year={2008}, volume={23}, pages={459-465} }