The association of the metabolic syndrome with QTc interval in NHANES III

Abstract

Purpose To examine the relationship of metabolic syndrome with corrected QT interval duration. Methods In a cross-sectional analysis of NHANES III, a representative sample of the adult US population, 3,495 individuals aged ≥40 years were categorized as having metabolic syndrome and not having metabolic syndrome as defined by ATP III. QT interval was measured from the standard 12-lead electrocardiogram. Results A weighted multi-linear regression analysis adjusted for age, gender, serum calcium, and potassium showed that metabolic syndrome was significantly associated with a corrected QT interval in milliseconds. The adjusted Beta coefficient and its corresponding standard error were (4.48 milliseconds, 0.95 milliseconds, P < 0.01). Conclusion These data indicate that metabolic syndrome is independently associated with a corrected QT interval duration. This study calls for careful ECG monitoring among persons with metabolic syndrome for early detection of a long corrected QT interval in order to prevent severe and often fatal arrhythmias.

DOI: 10.1007/s10654-008-9252-4

4 Figures and Tables

Statistics

05010020102011201220132014201520162017
Citations per Year

69 Citations

Semantic Scholar estimates that this publication has 69 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Faramawi2008TheAO, title={The association of the metabolic syndrome with QTc interval in NHANES III}, author={Mohammed F. Faramawi and Rachel P. Wildman and Jeanette Gustat and Janet C. Rice and Mohammed Y. Abdul Kareem}, journal={European Journal of Epidemiology}, year={2008}, volume={23}, pages={459-465} }