The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors.

@article{FigueroaVega2010TheAO,
  title={The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors.},
  author={Nict{\'e} Figueroa-Vega and Angel E D{\'i}az and Magdalena Adrados and Cristina {\'A}lvarez-Escol{\'a} and Amalia E Paniagua and Juli{\'a}n Aragon{\'e}s and Elena Mart{\'i}n-P{\'e}rez and Susanna Leskela and Ricardo Moreno-Otero and Roberto Gonz{\'a}lez-Amaro and M Ant{\'o}n Marazuela},
  journal={Endocrine-related cancer},
  year={2010},
  volume={17 4},
  pages={897-908}
}
The aim of this study was to explore the possible involvement of the angiopoietin (Ang)-1, -2/Tie-2 system in the development, growth, and metastases evolution of gastroenteropancreatic-neuroendocrine tumors (GEP-NETs). We prospectively examined the serum levels of Tie-2, Ang-1, and Ang-2 by ELISA in 42 patients with proven GEP-NETs and 27 controls. We also determined the expression of the Ang/Tie-2 system in freshly isolated peripheral blood monocytes and in tumor cells from malignant primary… CONTINUE READING
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