The association of maternal but not paternal genetic variation in GSTP1 with asthma phenotypes in children.

@article{Child2003TheAO,
  title={The association of maternal but not paternal genetic variation in GSTP1 with asthma phenotypes in children.},
  author={Frances Child and Warren Lenney and Sadie Clayton and Siobhan Davies and Paul W. Jones and Julie E Alldersea and Richard C. Strange and Anthony A Fryer},
  journal={Respiratory medicine},
  year={2003},
  volume={97 12},
  pages={
          1247-56
        }
}
Maternal factors including atopy and smoking during pregnancy are associated with asthma risk during childhood. Suggested mechanisms include transmission of specific maternal alleles and maternal influences on the intrauterine environment. We have previously shown that polymorphism in glutathione S-transferase, GSTP1 is associated with airway hyperresponsiveness (AHR) and atopy in adults. We now hypothesise that GSTP1 genotypes in the mother and child, but not the father, mediate asthma… CONTINUE READING
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