The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus.

@article{Lan2014TheAO,
  title={The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus.},
  author={Yan Lan and Bin Luo and Jun-li Wang and Yuan-Wen Jiang and Y-S Wei},
  journal={Gene},
  year={2014},
  volume={538 1},
  pages={94-8}
}
Systemic lupus erythematosus (SLE) is one of the common autoimmune diseases, with complex genetic components. Interleukin-21 (IL-21) is the most recently discovered member of the type-I cytokine family, which has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production. Previous studies have identified that IL-21 was associated with different autoimmune and inflammatory diseases, such as rheumatoid arthritis, multiple… CONTINUE READING
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Association of the −1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: a meta-analysis

  • B Wang
  • Gene
  • 2013

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