The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis.

@article{Liu2010TheAO,
  title={The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis.},
  author={Nan Liu and Xue-jun Li and Changqin Liu and Yongju Zhao and Bin Cui and Guang Ning},
  journal={Human immunology},
  year={2010},
  volume={71 4},
  pages={397-401}
}
The proinflammatory cytokine interleukin (IL)-1 family has a central role in mediating inflammation and joint destruction in Graves' disease (GD). A number of studies, investigating rs1800587 (IL-1alpha, T-889 C) and rs16944 (IL-1beta, A-511 G) polymorphisms to test their possible association with GD and Graves' ophthalmopathy (GO), had inconsistent results. Our study aims to further evaluate the possible association of these two polymorphisms with GD and GO within the Han Chinese population… CONTINUE READING

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