The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations.

@article{Wang2012TheAO,
  title={The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations.},
  author={X Wang and K Li and S Guo and H-N Qiang and L S Liu and Peter C. T. Song and Chao Wei and X-L Yi and Zhe Jian and Q Li and Chunying Li and T-W Gao},
  journal={The British journal of dermatology},
  year={2012},
  volume={166 5},
  pages={1081-7}
}
BACKGROUND Vitiligo is an acquired depigmentation disorder resulting from selective destruction of melanocytes. The aryl hydrocarbon receptor (AHR) is vital to the regulation of melanogenesis and melanocyte proliferation and differentiation through modulating the expressions of melanogenesis-related genes. AHR mutations may negatively affect AHR proteins and its target genes. Therefore, we hypothesized that AHR polymorphisms might be involved in vitiligo by impacting the transcriptional… CONTINUE READING