The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor.

@article{Chen1996TheAO,
  title={The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor.},
  author={Hao Chen and Jun-Lin Guan},
  journal={European journal of biochemistry},
  year={1996},
  volume={235 3},
  pages={495-500}
}
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase implicated in the signal transduction pathways initiated by integrins. However, we have previously found that platelet-derived growth factor (PDGF) could stimulate the association of FAK with phosphatidylinositol 3-kinase in NIH 3T3 cells [Chen, H.-C. & Guan, J.-L. (1994) J. Biol. Chem 269, 31229-31223], suggesting that FAK might participate in some of the cellular effects of the growth factors in modulating cell morphology and… CONTINUE READING