The association of elevated urinary total to sulfated glycosaminoglycan ratio and high molecular mass hyaluronic acid with interstitial cystitis.

@article{Wei2000TheAO,
  title={The association of elevated urinary total to sulfated glycosaminoglycan ratio and high molecular mass hyaluronic acid with interstitial cystitis.},
  author={David C. Tou Wei and Victor A Politano and Marie G. Selzer and Vinata B. Lokeshwar},
  journal={The Journal of urology},
  year={2000},
  volume={163 5},
  pages={1577-83}
}
PURPOSE A decrease in the glycosaminoglycan (GAG) layer on the urothelium is believed to be one of the possible causes of interstitial cystitis. Consequently, GAG-like substances and hyaluronic acid (HA) have been prescribed for treating this condition. To delineate the possible role of GAG and HA in the interstitial cystitis disease process, we compared the urinary levels of total GAGs (sulfated + non-sulfated), sulfated GAGs and HA in interstitial cystitis patients and normal controls. We… CONTINUE READING