The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.

@article{Hershey1997TheAO,
  title={The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.},
  author={Gurjit K. Khurana Hershey and Michael Friedrich and L A Esswein and Michelle L. Thomas and Talal A Chatila},
  journal={The New England journal of medicine},
  year={1997},
  volume={337 24},
  pages={1720-5}
}
BACKGROUND Atopic diseases are very common, and atopy has a strong genetic predisposition. METHODS Using single-strand conformation polymorphism analysis and DNA sequencing, we searched for mutations in the a subunit of the interleukin-4 receptor that would predispose persons to atopy. We examined the prevalence of the alleles among patients with allergic… CONTINUE READING