The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer

@article{Ellis1995TheAO,
  title={The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer},
  author={J C Ellis and Peter J. Keating and John Baird and Elizabeth F. Hounsell and David V. Renouf and Martin Rowe and Donna Hopkins and Maggie F. Duggan-Keen and J. S. Bartholomew and Lisa S Young and Peter L. Stern},
  journal={Nature Medicine},
  year={1995},
  volume={1},
  pages={464-470}
}
HLA-restricted cytotoxic T-lymphocyte (CTL) recognition of human papillomavirus (HPV) oncogene products may be important in the control of the HPV infections associated with the development of cervical cancer. We have identified, in HLA-B7 individuals, a consistent variation in the HPV16 E6 oncoprotein sequence, which alters an HLA-B7 peptide binding epitope in a way likely to influence immune recognition by CTLs. These results illustrate a biologically relevant mechanism for escape from immune… CONTINUE READING
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