The association of aggrecan gene polymorphism with the risk of intervertebral disc degeneration

@article{Kim2010TheAO,
  title={The association of aggrecan gene polymorphism with the risk of intervertebral disc degeneration},
  author={Nam Keun Kim and Dong Ah Shin and In Bo Han and Eun Hye Yoo and Sang Heum Kim and Sang Sup Chung},
  journal={Acta Neurochirurgica},
  year={2010},
  volume={153},
  pages={129-133}
}
Intervertebral disc degeneration is now considered to be genetically determined in large part, with environmental factors also playing an important role. The human is known to uniquely exhibit variable numbers of tandem repeat polymorphism within the aggrecan CS1 domain. To date, the analysis of aggrecan’s variable numbers of tandem repeat polymorphism has given inconsistent results with respect to the correlation between the allele’s size and intervertebral disc degeneration. We wanted to… CONTINUE READING

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