The association of CD18 alleles with anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides.

@article{Genk2000TheAO,
  title={The association of CD18 alleles with anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides.},
  author={Martin Gen{\vc}{\'i}k and Sebastian Meller and Stefan Borgmann and Thomas Sitter and A M Menezes Saecker and Harald Fricke and Joerg T. Epplen},
  journal={Clinical immunology},
  year={2000},
  volume={94 1},
  pages={
          9-12
        }
}
Wegener granulomatosis (WG), microscopic polyangiitis (MP), and Churg Strauss syndrome (CSS) are rare systemic autoimmune disorders. Common features are anti-neutrophil cytoplasmic antibodies (ANCA) in patient sera. Whereas WG patients show mainly anti-proteinase 3 ANCA, MP and CSS patients typically present anti-myeloperoxidase (MPO) ANCA. ANCA play an important role in the pathogenesis in the vessel wall by activating polymorphonuclear cells (PMN) and increased adhesivity between PMN and… CONTINUE READING
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