The association between leptin and depressive symptoms is modulated by abdominal adiposity.

@article{Milaneschi2014TheAB,
  title={The association between leptin and depressive symptoms is modulated by abdominal adiposity.},
  author={Yuri Milaneschi and Angelina R Sutin and A. Terracciano and Marco Canepa and Kristofer S. Gravenstein and Josephine M. Egan and Nicole Vogelzangs and Jack Guralnik and Stefania Bandinelli and Brenda W J H Penninx and Luigi Ferrucci},
  journal={Psychoneuroendocrinology},
  year={2014},
  volume={42},
  pages={1-10}
}
BACKGROUND Evidence for a role of leptin in depression is limited and conflicting. Inconclusive findings may be explained by the complex effect of obesity on leptin signaling. In particular, both hyperleptinemia due to leptin resistance in obese persons as well as low leptin in lean persons can imply that low leptin biological signaling is associated with an increased risk of significant depressive symptoms. We tested whether the relationship between leptin and depressive symptoms is modulated… CONTINUE READING
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