The association between kidney disease and cardiovascular risk in a multiethnic cohort: findings from the Northern Manhattan Study (NOMAS).

Abstract

BACKGROUND AND PURPOSE The objective of this study was to determine the relationship between chronic kidney disease (CKD), race-ethnicity, and vascular outcomes. METHODS A prospective, multiracial cohort of 3298 stroke-free subjects with 6.5 years of mean follow-up time for vascular outcomes (stroke, myocardial infarction, vascular death) was used. Kidney function was estimated using serum creatinine and Cockcroft-Gault formula. Cox proportional hazards models were fitted to evaluate the relationship between kidney function and vascular outcomes. RESULTS In multivariate analysis, Cockcroft-Gault formula between 15 and 59 mL/min was associated with a significant 43% increased stroke risk in the overall cohort. Blacks with Cockcroft-Gault formula between 15 and 59 mL/min had significantly increased risk of both stroke (hazard ratio, 2.65; 95% CI, 1.47 to 4.77) and combined vascular outcomes (hazard ratio, 1.59; 95% CI, 1.10-2.92). CONCLUSIONS Chronic kidney disease is a significant risk factor for stroke and combined vascular events, especially in blacks.

DOI: 10.1161/STROKEAHA.107.513713

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@article{Nickolas2008TheAB, title={The association between kidney disease and cardiovascular risk in a multiethnic cohort: findings from the Northern Manhattan Study (NOMAS).}, author={Thomas L. Nickolas and Minesh Khatri and Bernadette Boden-Albala and Krzysztof Kiryluk and Xiaodong Luo and Palma Gervasi-Franklin and Myunghee Cho Paik and Ralph L. Sacco}, journal={Stroke}, year={2008}, volume={39 10}, pages={2876-9} }