The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study.

@article{Lakoski2007TheAB,
  title={The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study.},
  author={Susan G. Lakoski and Liwu Li and Carl D. Langefeld and Yongmei Liu and Timothy D. Howard and K. Bridget Brosnihan and Jianfeng Xu and Donald W. Bowden and David M. Herrington},
  journal={Experimental and molecular pathology},
  year={2007},
  volume={82 3},
  pages={280-3}
}
UNLABELLED Evidence suggests that interleukin-1 receptor-associated kinase-1 (IRAK1), fundamental in the toll-like receptor pathway (TLR), may play a more specific role in atherosclerosis. METHODS Caucasian women (N=529) and men (N=467) from the Diabetes Heart Study (DHS) were genotyped at four loci within the IRAK1 gene located on the X chromosome. Generalized estimating equations (GEE1) were used to evaluate association with C-reactive protein (CRP) for both single SNP and haplotype… CONTINUE READING