The association between injected volume of local anesthetic and spread of epidural anesthesia: a hypothesis.

@article{Kaneko1999TheAB,
  title={The association between injected volume of local anesthetic and spread of epidural anesthesia: a hypothesis.},
  author={Tadashi Kaneko and Hiroshi Iwama},
  journal={Regional anesthesia and pain medicine},
  year={1999},
  volume={24 2},
  pages={153-7}
}
BACKGROUND AND OBJECTIVES Clinically, an increase of the injected volume of local anesthetic does not result in a linear increase in the spread of epidural anesthesia. This study was designed to evaluate this observation. METHODS One-hundred twenty adult women undergoing abdominal gynecologic surgery were randomly assigned into 6 groups of 20 patients each. An epidural catheter was inserted in each patient via the L1-L2 interspace, and 2, 4, 6, 8, 10, and 12 mL of 2% mepivacaine was injected… CONTINUE READING