The association between glutathione S-transferase P1 genotype and plasma level in head and neck cancer.

@article{Kelders2002TheAB,
  title={The association between glutathione S-transferase P1 genotype and plasma level in head and neck cancer.},
  author={Willem P A Kelders and Michael B Oude Ophuis and Hennie M. J. Roelofs and Wilbert H. M. Peters and Johannes Jan Manni},
  journal={The Laryngoscope},
  year={2002},
  volume={112 3},
  pages={
          462-6
        }
}
OBJECTIVES/HYPOTHESIS Glutathione S-transferase P1-1 (GSTP1-1) is an important enzyme because it plays a major role in many detoxification reactions, including tobacco-related metabolic products. GSTP1-1 is the most abundant of all glutathione S-transferase (GST) enzymes in normal human head and neck epithelium, whereas it is overexpressed in head and neck malignancies. At least three different GSTP1 genotypes exist, AA, AB, and BB, which have been correlated with reduced enzyme activity. Many… CONTINUE READING