The association between endothelial nitric oxide synthase gene G894T polymorphism and hypertension in Han Chinese: a case-control study and an updated meta-analysis

@article{Liu2015TheAB,
  title={The association between endothelial nitric oxide synthase gene G894T polymorphism and hypertension in Han Chinese: a case-control study and an updated meta-analysis},
  author={Jie-lin Liu and Li-juan Wang and Ya Liu and Zuo-guang Wang and Mei Li and Bei Zhang and Hao Wang and Kuo Liu and Shaojun Wen},
  journal={Annals of Human Biology},
  year={2015},
  volume={42},
  pages={185 - 195}
}
Abstract Background: The G894T (rs1799983) polymorphism in endothelial nitric oxide synthase (eNOS/NOS3) gene has been implicated in susceptibility to essential hypertension (EH) in some studies, but no clear consensus has been reached in the Chinese population. Aims: This study aimed to investigate the association of the G894T polymorphism and EH in Han Chinese. Subjects and methods: First, a case-control study was performed involving 1525 subjects in northern Han Chinese to study the… 

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References

SHOWING 1-10 OF 68 REFERENCES

Endothelial nitric oxide synthase G894T gene polymorphism and essential hypertension in the Chinese population: a meta-analysis involving 11,248 subjects.

TLDR
T allele of eNOS G894T gene was suggested to be related to the increased risk of EH in the Chinese population, particularly in those of Han ethnicity.

Endothelial Nitric Oxide Synthase G894T Gene Polymorphism and Essential Hypertension in the Chinese Population: a Meta-Analysis Involving 11,248 Subjects

TLDR
T allele of eNOS G894T gene was suggested to be related to the increased risk of EH in the Chinese population, particularly in those of Han ethnicity.

Association study of the endothelial nitric oxide synthase gene polymorphisms with essential hypertension in northern Han Chinese.

TLDR
The study results suggest that the three eNOS gene polymorphisms are unlikely to be major genetic susceptibility factors for essential hypertension in the northern Han Chinese population.

Association of eNOS gene polymorphisms with essential hypertension in the Han population in southwestern China.

TLDR
The results suggest that the eNOS polymorphism is one of the factors contributing to the predisposition for essential hypertension in the Han population in southwestern China.

Relationship between G894T Polymorphism of Endothelial Nitric Oxide Synthesis Gene and Essential Hypertension in Han Ethnicity of Ningxia

TLDR
It may not be association between the G894T polymorphism of eNOS gene and essential hypertension in Han ethnicity of Ningxia.

ENOS-G894T polymorphism is a risk factor for essential hypertension in China.

TLDR
The study demonstrated a significant and independent association between a eNOS-G894T polymorphism and EH in the Chinese patients and showed that eNos-G895T polymorphisms is a risk factor for Eh in Chinese patients.

Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study

TLDR
The evidence of the study does not support the major contributory role of these common NOS3 variants in preeclampsia, and the analysis of haplotypes showed lack of significant association.

Association of Polymorphisms G894T and T786C in the Endothelial Nitric Oxide Synthase Gene with the risk of Essential Hypertension in Mongulia Population

TLDR
eNOS (G894T) polymorphisms are associated with essential Hypertension (EH) in mongulia, however, it still need to be test in a larger population.

Association of Endothelial Nitric Oxide Synthase Gene Polymorphism with Essential Hypertension

TLDR
The polymorphism of eNOS G894T was not associated with EH, while the polymorphism with intron 4th VNTR was associated withEH, but there was no significant synergistic effect of the two polymorphism on EH.
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