The association between burnout, depression, anxiety, and inflammation biomarkers: C-reactive protein and fibrinogen in men and women.

@article{Toker2005TheAB,
  title={The association between burnout, depression, anxiety, and inflammation biomarkers: C-reactive protein and fibrinogen in men and women.},
  author={Sharon Toker and Arie Shirom and Itzhak Shapira and Shlomo Berliner and Samuel Melamed},
  journal={Journal of occupational health psychology},
  year={2005},
  volume={10 4},
  pages={
          344-62
        }
}
Following the demonstrated association of employee burnout or vital exhaustion with several risk factors for cardiovascular disease (CVD) and CVD risk, the authors investigated the possibility that one of the mechanisms linking burnout with CVD morbidity is microinflammation, gauged in this study by high-sensitivity C-reactive protein (hs-CRP) and fibrinogen concentrations. Their sample included 630 women and 933 men, all apparently healthy, who underwent periodic health examinations. The… 

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References

SHOWING 1-10 OF 165 REFERENCES
Burnout and risk factors for cardiovascular diseases.
TLDR
The authors found that scores on burnout plus tension (tense-burnout) were associated with somatic complaints, cholesterol, glucose, triglycerides, uric acid, and, marginally, with ECG abnormalities.
Physiological correlates of burnout among women.
Association Between Depression and Elevated C-Reactive Protein
TLDR
A recent history of major depressive episode is strongly associated with elevated CRP in men aged 17 to 39, and this group, low-grade systemic inflammation could represent a mechanism linking depression to cardiovascular risk.
Relationship Between Depression and C-Reactive Protein in a Screening Population
TLDR
Depressive symptoms are only weakly correlated with CRP, and the relationship between depression and clinical coronary disease is unlikely to be explained through direct effects on CRP levels, but may be mediated by BMI.
Elevated Plasma C-Reactive Protein in Chronically Distressed Subjects Who Carry the A Allele of the TNF-α −308 G/A Polymorphism
TLDR
The findings suggest that the A allele of the TNF-α −308 G/A polymorphism may mediate inflammation with exhaustion in a dose-response relationship, while with the GG wild-type exhaustion severity seems unrelated to CRP levels.
Inflammatory cytokines, socioeconomic status, and acute stress responsivity
Association between burnout at work and leukocyte adhesiveness/aggregation.
TLDR
Total burnout and each of its subcomponents, emotional exhaustion, chronic fatigue, and cognitive weariness, was significantly associated with LAA levels, even after controlling for age, sex, and educational level.
...
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