The association between Mi-2 antibodies and dermatomyositis.

  title={The association between Mi-2 antibodies and dermatomyositis.},
  author={Ira N. Targoff and Morris Reichlin},
  journal={Arthritis and rheumatism},
  volume={28 7},
Antibodies to Mi, an antigen in calf thymus extract, have been demonstrated by complement fixation inhibition in polymyositis (PM) and dermatomyositis (DM) sera but not in the sera of individuals without myositis. The original Mi reference serum defined 2 precipitating antibodies, using immunodiffusion (ID). Anti-Mi-1 was not active in complement fixation. We have now studied in further detail anti-Mi-2, which appears to be the antibody in Mi serum that fixes complement. Mi-2 antigen was… CONTINUE READING