The association between CYP19 polymorphism and endometriosis risk: a system review and meta-analysis.

  title={The association between CYP19 polymorphism and endometriosis risk: a system review and meta-analysis.},
  author={Ke Yi and L. Yang and Zhu Lan and M. Xi},
  journal={European journal of obstetrics, gynecology, and reproductive biology},
  • Ke Yi, L. Yang, +1 author M. Xi
  • Published 2016
  • Medicine
  • European journal of obstetrics, gynecology, and reproductive biology
OBJECTIVE Endometriosis is a chronic, inflammatory, estrogen dependent disease. Genetic variation of estrogen biosynthesis and metabolic genes is associated with the risk of endometriosis. The CYP19 gene, encoding aromatase, plays an important role in the conversion of androgens to estrogens. Polymorphisms in the CYP19 gene are associated with circulating estrogen levels and estrogen/testosterone ratio. The aim of present study is to evaluate the impact of the CYP19 rs10046 polymorphism on… Expand
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