The association between 2D:4D ratio and cognitive empathy is contingent on a common polymorphism in the oxytocin receptor gene (OXTR rs53576)

@article{Weisman2015TheAB,
  title={The association between 2D:4D ratio and cognitive empathy is contingent on a common polymorphism in the oxytocin receptor gene (OXTR rs53576)},
  author={Omri Weisman and Kevin A. Pelphrey and James Frederick Leckman and Ruth Feldman and Yunfeng Lu and Anne Chong and Ying Chen and Mikhail V Monakhov and Soo Hong Chew and Richard P. Ebstein},
  journal={Psychoneuroendocrinology},
  year={2015},
  volume={58},
  pages={23-32}
}
View on Elsevier
doi.org
53 Citations
Highly Influential Citations
2
Background Citations
10
Methods Citations
1

Figures and Tables from this paper

53 Citations

The influence of rs53576 polymorphism in the oxytocin receptor (OXTR) gene on empathy in healthy adults by subtype and ethnicity: a systematic review and meta-analysis
TLDR
A systematic review and meta-analysis of the effects of rs53576 on subdomains of empathy, specifically cognitive empathy (CE) and affective empathy (AE) in healthy adults found G homozygotes had greater generalized empathic abilities only in young to middle-aged adults.
Physical activity associates empathy in Japanese young adults with specific gene variations of oxytocin receptor and vasopressin V1B receptor
Oxytocin receptor gene polymorphism (rs53576) and digit ratio associates with aggression: comparison in seven ethnic groups
TLDR
The data suggest that both oxytocin ( OXTR gene polymorphism) and fetal testosterone (2D:4D) may significantly affect emotional (anger) and cognitive (hostility) aggression in humans, given the leveling the role of culture.
Revisiting the impact of OXTR rs53576 on empathy: A population-based study and a meta-analysis
The OXTR Single-Nucleotide Polymorphism rs53576 Moderates the Impact of Childhood Maltreatment on Empathy for Social Pain in Female Participants: Evidence for Differential Susceptibility
TLDR
Together, A-allele carriers, especially those with BPD, seemed to be responsive to the impact of adversity on empathy-for-pain, while GG homozygotes were not, which is compatible with the idea of differential susceptibility.
OXTR rs53576 polymorphism impacts interpersonal adaptability: Dispositional forgiveness as a mediator
Oxytocin and Interpersonal Relationships.
TLDR
It is argued that OT continues to hold strong therapeutic promise, but that it is strongly dependent on internal and external influences, for instance the patient's personal past experiences and interaction with the therapist, in order to provide the best possible therapy.
Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity
TLDR
The findings provide further support for the role of oxytocin in facilitating emotional empathy and demonstrate that effects are independent of culture and sex and involve modulatory effects on the amygdala and its interactions with other key empathy regions.
Gene X Environment Interactions and Pillow Talk: Investigating the Associations among the OXTR Gene, Orgasm, Post Sex Communication, and Relationship Satisfaction in Young Adult Relationships
ABSTRACT The present investigation tested the effects of a gene x environment interaction on sexual communication and relational well-being. It was hypothesized that the interaction of variation in…
Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children
TLDR
It is suggested that OXTR may be associated with discrete neurocognitive abilities in childhood, and these effects may be modulated by intrauterine conditions related to fetal growth and development.
...
...

References

SHOWING 1-10 OF 90 REFERENCES
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
TLDR
The results provide evidence of how a naturally occurring genetic variation of the oxytocin receptor relates to both empathy and stress profiles and suggest that AA/AG individuals displayed higher physiological and dispositional stress reactivity than GG individuals.
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function
TLDR
Evidence for structural alterations in key oxytocinergic regions emerged, particularly in the hypothalamus, and these neural characteristics predicted lower levels of reward dependence in male risk allele carriers.
Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratio
TLDR
It is shown that administration of testosterone in 16 young women led to a significant impairment in their cognitive empathy, and that this effect is powerfully predicted by a proxy of fetal testosterone: the right-hand second digit-to-fourth digit ratio.
Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others
TLDR
The hypothesis that genetic variation in OXTR is associated with autonomic reactions when perceiving others in distress is examined and the importance of the oxytocin receptor variation in emotional and physiological reactions to the affective experiences of other conspecifics is supported.
Associations between the oxytocin receptor gene (OXTR) and “mind-reading” in humans—An exploratory study
TLDR
This study adds further evidence to the hypothesis that genetic variations in the OXTR modulate mind-reading and social behaviour.
Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament
TLDR
This work revealed that female subjects with the AA genotype showed increased harm avoidance scores relative to G-carrier females, and highlighted a possible neural pathway by which a naturally occurring variation of the OXTR gene may affect an anxiety-related temperamental trait in female subjects by modulating prefrontal-amygdala functional connectivity.
Oxytocin, testosterone, and human social cognition
  • B. Crespi
  • Psychology, Biology
    Biological reviews of the Cambridge Philosophical Society
  • 2016
I describe an integrative social‐evolutionary model for the adaptive significance of the human oxytocinergic system. The model is based on a role for this hormone in the generation and maintenance of…
Variation in oxytocin receptor gene (OXTR) polymorphisms is associated with emotional and behavioral reactions to betrayal.
Variations in the gene that encodes the oxytocin receptor (OXTR) have been associated with many aspects of social cognition as well as several prosocial behaviors. However, potential associations of…
Oxytocin receptor and vasopressin receptor 1a genes are respectively associated with emotional and cognitive empathy
Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans
TLDR
Results indicate that genetic variation of the oxytocin system modulates the effectiveness of positive social interaction as a protective buffer against a stressful experience.
...
...