The assignment of PRKCI to bovine chromosome 1q34→q36 by FISH suggests a new assignment to human chromosome 3

@article{DeDonato2001TheAO,
  title={The assignment of PRKCI to bovine chromosome 1q34→q36 by FISH suggests a new assignment to human chromosome 3},
  author={Marcos De Donato and D.S. Gallagher Jr. and Scott K. Davis and David M. Stelly and J.F. Taylor},
  journal={Cytogenetic and Genome Research},
  year={2001},
  volume={95},
  pages={79 - 81}
}
Two bovine BAC clones were identified by PCR as containing the bovine gene PRKCI. Both clones were assigned by FISH to bands q34→q36 on BTA1. The sequence information derived from genomic DNA and from both clones was identical and showed a high degree of homology to human PRKCI (HSAXq21.3, 95.5% homology), and mouse Prkcl (MMU3, 13.8 cM, 87.6% homology) and rat Prkcl (88.8% homology). This assignment could suggest a disruption of the synteny conservation of mammalian X-linked genes, but most… 
3 Citations

Figures from this paper

Novel immunohistochemical markers for the differentiation of lobular and ductal invasive breast carcinomas.

Apart from the well-established marker, E-cadherin, proteins examined on TMA slides by immunohistochemistry may represent novel tissue markers helpful in the differentiation of ductal and lobular breast cancers.

References

SHOWING 1-10 OF 10 REFERENCES

Comparative gene mapping: a fine-scale survey of chromosome rearrangements between ruminants and humans.

This comprehensive map of goat chromosomes will speed up positional cloning projects in domestic ruminants and clarify some aspects of mammalian chromosomal evolution.

Localization of ZNF164, ZNF146, GGTA1, SOX2, PRLR and EEF2 on homoeologous cattle, sheep and goat chromosomes by fluorescent in situ hybridization and comparison with the human gene map.

The comparison of the results with the localization of these genes in man confirm the correspondences between human and bovine chromosomes established from heterologous chromosome painting data.

Physical assignment of microsatellite- containing BACs to bovine chromosomes

The physical assignment of 40 microsatellite markers by fluorescence in situ hybridization to 13 different bovine chromosomes is reported for the purpose of integrating the linkage maps of these chromosomes to their physical maps and determining the physical coverage of these linkage groups.

Genetic mapping of a gene encoding an atypical protein kinase C, protein kinase C lambda, to the proximal region of mouse chromosome 3.

Protein kinase C are a class of proteins that mediate the control of cellular responses to external stimuli through the phosphorylation of target proteins. These proteins show a molecular

The bovine genes for phosphoglycerate kinase, glucose-6-phosphate dehydrogenase, alpha-galactosidase, and hypoxanthine phosphoribosyltransferase are linked to the X chromosome in cattle-mouse cell hybrids.

Data indicated that the genes for G6PD, PGK, and HPRT are linked and can be assigned to the bovine X chromosome.

Database divisions and homology search files: a guide for the perplexed.

This work focuses on the manner in which high-throughput genomic sequence is processed, distributed, and made available for BLAST searching, with an emphasis on services provided through NCBI.

International System for Cytogenetic Nomenclature of Domestic Animals (1989)

The objectives of this meeting were to update the standard karyotypes of cattle,goat,and sheep established at the first meeting in Reading.

Ancient Linkage Groups and Frozen Accidents

Evidence is presented that the genetic differences between man and the other mammals are extremely small. This supports the concept that natural selection conserves the status quo. The idea of