The assessment of cellular proliferation by immunohistochemistry: A review of currently available methods and their applications

@article{Yu1992TheAO,
  title={The assessment of cellular proliferation by immunohistochemistry: A review of currently available methods and their applications},
  author={Cermen C. -W. Yu and Amanda L. Woods and David A. Levison},
  journal={The Histochemical Journal},
  year={1992},
  volume={24},
  pages={121-131}
}
Immunohistochemical methods using antibodies to cell cycle-related antigens may be used as a means of assessing various aspects of proliferation in tissue, and have the important advantage of preserving the spatial orientation of proliferating cells in histological sections. Currently, the most widely available antibodies for this purpose are antibodies to bromodeoxyuridine (BrdU), Ki67 and antibodies to proliferating cell nuclear antigen (PCNA). BrdU is a thymidine analogue incorporated during… CONTINUE READING
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