The assembly of the major desmosome glycoproteins of Madin-Darby canine kidney cells.


Madin-Darby canine kidney (MDCK) cells are unable to form desmosomes when cultured in low-calcium medium [( Ca2+] less than 0.1 meq./l), but can be induced to do so by raising the calcium to physiological concentrations (1-2 meq./l). We have previously demonstrated that this block correlated with increased desmosomal protein turnover. Here we have… (More)


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