The assembly and immunological properties of non-linear synthetic immunogens containing T-cell and B-cell determinants.

@article{Fitzmaurice1996TheAA,
  title={The assembly and immunological properties of non-linear synthetic immunogens containing T-cell and B-cell determinants.},
  author={Christina Fitzmaurice and Lorena Elizabeth Brown and T L McInerney and David C Jackson},
  journal={Vaccine},
  year={1996},
  volume={14 6},
  pages={553-60}
}
For the rational design of synthetic vaccines, a potential immunogen must contain the appropriate helper T-cell and B-cell determinants to elicit a strong and relevant immune response. In this study we describe a method for the assembly of antigenic determinants from influenza virus hemagglutinin onto a lysine-based support, resulting in dimeric and trimeric constructs bearing both T-cell and B-cell determinants. A panel of synthetic immunogens was constructed incorporating peptides… CONTINUE READING

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